You will need to install new drivers drivers (particularly chipset drivers) as due to the differences in chipset architecture between them.
All in all its not a bad thing as you just boot to safe mode, uninstall the chipset drivers and transfer the hdd across to the new board. then install the new chipset drivers, they you are off running.
Once you have done you r bench marking and decided what set up you are going to use. My advise is to reinstall the OS, so any remnants of previously installed drivers cannot cause a problem in the future.
I tried it like this.
I decided to skip testing and just took what i thought was best.
Comp parts 1: MSI 6728 (Motherboard), p4 2.8GHz, PowerColor x1650 XT with Accelero S2.
Comp parts 2: ECS NFORCE3-A939, AMD Athlon X2 4200+, Geforce 6600GT.
So all i did was remove MB and CPU from the Chassi and inserted the new stuff. Rewired everything and hit boot. It started up but got bluescreen at windows loading sign, even with safe mode. Do i have to uninstall old motherboard chipset driver before i insert the new stuff?