I don't know if discussion about other projects is permitted or welcome here but I just wanted to point out one specific project.
It is protein folding from a different perspective and uses the Boinc system rather than a standalone or GUI client.
A mini FAQ can be found HERE
The project is still in early stages and has less than 2000 participants but is growing steadily.
The server has proven very reliable in the time I've run the project and work unit availability has never been an issue.
Anyway, I thought some folk may at least be interested in taking a look.