After more than a month since I sent that e-mail to CNN, I realized that they don't have any interest in unveiling
a possible treatment for Ebola, since the more people get sick and die, the more important the news they can show.
Here is the evolution of the epidemic, it seems to double each month:
After thinking about the people most interested in a possible treatment, I decided that Medecins sans frontieres might
want this kind of information, so yesterday I sent an e-mail to their London office, the contents is below:
Since you seem to have your hands full with the Ebola epidemic, and any useful information may save lives,
please take a bit of time to read a couple of medical papers that address possible Ebola treatments:
Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal modelhttp://www.sciencedirect.com/science/ar ... 4214000576
FDA-Approved Selective Estrogen Receptor Modulators Inhibit Ebola Virus Infectionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955358/
If you already knew about these papers, please disregard this e-mail.
Favipiravir is already in clinical phase 3 testing against influenza, so it's relatively safe to use at the MTD and probably can be sourced
from Medivector in quantities good for 1,000 - 2,000 patients. It probably is expensive at this stage.http://www.medivector.com/favipiravir/favipiravir1
Clomiphene has been used since the 1960s, is cheap and can be sourced in large quantities.
Other substances (toremiphene, chloroquine, amodiaquine, ketotifen, diphenoxylate, amiodarone, dronedarone, verapamil)
also showed activity against Ebola virus, but not as good as clomiphene (90% protection in mice).http://en.wikipedia.org/wiki/Clomiphene
I do believe that a combination treatment Favipiravir + Clomiphene should be effective, considering that by the time most
patients would start treatment, their virus burden will be quite high. Clomiphene might buy enough time (seems to be about 2 days),
by delaying the infection of new cells, for Favipiravir to significantly drop the viremia.
Supportive therapy will still be very important even if a regimen will effectively kill the virus, because the destruction of lymphocytes,
increases in circulating cytokine levels and development of coagulation abnormalities will take some time to return to normal.